Tamoxifen


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Tamoxifen


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Description

Tamoxifen

GENERAL INFORMATION:

Manufacturer: TEVA Pharmaceutical, Hungary
Substance: Tamoxifen Citrate
Package: 30 tabs (10 mg/tab)

Active Life: 5-7 days
Drug Class: Selective Estrogen Receptor Modulator (Oral)
Average Dose: 10-30 mg/day
Acne: Yes
Water Retention: No
High Blood Pressure: Rare
Liver Toxic: low

Tamoxifen Citrateis a non-steroidal agent that demonstrates potent anti-estrogenic properties. The drug is technically an estrogen agonist/antagonist, which competitively binds to estrogen receptors in various target tissues. With the tamoxifen molecule bound to this receptor, estrogen is blocked from exerting any action, and an anti-estrogenic effect is achieved. Since many forms of breast cancer are responsive to estrogen, the ability of tamoxifen citrate to block its action in such cells has proven to be a very effective treatment. It is also utilized successfully as a preventative measure, taken by people with an extremely high familial tendency for breast cancer. While Nolvadex is effective against estrogen, it is not our strongest available remedy. We now have the drugs Arimidex, Femara, and Aromasin available to us, which notably prevents estrogen from being manufactured in the first place. Altering the effect of estrogen in the female body can cause a level of discomfort, so anti-estrogens are most bearable when used after the point of menopause. Since Nolvadex is milder in comparison, it is more widely applicable and usually the first treatment option.

As discussed earlier, an enzyme in the male body (aromatase) is capable of altering testosterone to form estradiol. The structure of estrogen is actually quite similar to testosterone, so its presence in the male body is not all that remarkable. Since this same enzyme can also aromatize many anabolic/androgenic steroids, the buildup of estrogens can be an important concern during intake. High levels can cause a number of unwanted side effects, a primary worry being gynecomastia or the development of female breast tissue in men. This can be first noticed by the appearance of swelling or a small lump under the nipple. If left to progress it can turn into a very unsightly development of tissue, often irreversible without surgery. Estrogen can also lead to an increase in the level of water retained in the body. The result here can be a notable loss of definition, the muscles beginning to look smooth and bloated due to the retention of subcutaneous fluid. Fat storage may also be increased as estrogen levels rise. This hormone is in fact the primary reason women have a higher body fat percentage, and different fat distribution (hips/thighs) than men. Individuals sensitive to the effects of estrogen will usually be sure to have an anti-estrogen on hand when taking problematic steroids, so as to minimize the impact of related side effects.

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